Effects of Metformin, Avocado Seed, and Diabetic Ingredients Infusion to Weight and Fasting Blood Glucose on Sucrose Diet Rats

Metformin, an oral hypoglycemic drug which has metabolic effects and weight loss after 6–9 months; however, after 18 months, these effects disappear. Oral hypoglycemic drugs with no effect on raising the weight are needed. The objective of the study is comparing the effects of metformin, avocado seed infusion (AS), and diabetic ingredients/DI (green chiretta, Java tea, and bitter grapes) in increasing weight and fasting blood glucose of rats with sucrose diet. The research was conduct at the Pharmacology Laboratory, Faculty of Medicine Universitas Kristen Maranatha in February–August 2017. The results showed that metformin within six weeks reduced weight (75.55%) compared to control (+) with a hypercaloric diet (114.36%). Metformin and hypercaloric diet in rats for 14 weeks showed a 125.66% increase in weight, higher than control (+) (114.36%), although not significant (p>0.05). Weight in rats with hypercaloric and AS diet for 14 weeks was 94.30% and 81.68% in DI was lower than control (+) (114.36%), but not significant (p>0.05). Fasting blood glucose (FBG) of dietary hypercaloric rats and metformin was 123.75 mg/dL, higher than control (+), which was 85.75 mg/dL (p<0.01), whereas FBG infusion of AS and DI during 14 weeks: 85.75 mg/dL, and 99.50 mg/dL, not significant to control (+) (p>0.05). In conclusions, metformin increased rats body weight even though not significantly and fasting blood glucose in rats fed a hypercaloric diet for 14 weeks, while avocado seed infusion and diabetec ingredients infusion did not.